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1

Structure characterization of flavonoid O-diglycosides by positive and negative nano-electrospray ionization ion trap mass spectrometry

Filip Cuyckens, Raoul Rozenberg, Edmond de Hoffmann, Magda Claeys

Journal:

Journal of Mass Spectrometry

Année:

2001

Langue:

english

Fichier:

PDF, 161 KB

english, 2001

2

Mass spectrometry in the structural analysis of flavonoids

Filip Cuyckens, Magda Claeys

Journal:

Journal of Mass Spectrometry

Année:

2004

Langue:

english

Fichier:

PDF, 389 KB

english, 2004

3

Optimization of a liquid chromatography method based on simultaneous electrospray ionization mass spectrometric and ultraviolet photodiode array detection for analysis of flavonoid glycosides

Filip Cuyckens, Magda Claeys

Journal:

Rapid Communications in Mass Spectrometry

Année:

2002

Langue:

english

Fichier:

PDF, 159 KB

english, 2002

4

Structural characterization of chromone C-glucosides in a toxic herbal remedy

Wu Wang, Filip Cuyckens, Hilde Van den Heuvel, Sandra Apers, Luc Pieters, Vanessa Steenkamp, Michael J. Stewart, Valerie A. Luyckx, Magda Claeys

Journal:

Rapid Communications in Mass Spectrometry

Année:

2003

Langue:

english

Fichier:

PDF, 175 KB

english, 2003

5

Use of the bromine isotope ratio in HPLC-ICP-MS and HPLC-ESI-MS analysis of a new drug in development

Filip Cuyckens, Lieve I. L. Balcaen, Kenny De Wolf, Bjorn De Samber, Cis Van Looveren, Rob Hurkmans, Frank Vanhaecke

Journal:

Analytical and Bioanalytical Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 421 KB

english, 2008

6

Speciation analysis of bromine-containing drug metabolites in feces samples from a humanin vivostudy by means of HPLC/ICP-MS combined with on-line isotope dilution

Björn Meermann, Marc Bockx, Aline Laenen, Cis Van Looveren, Filip Cuyckens, Frank Vanhaecke

Journal:

Analytical and Bioanalytical Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 493 KB

english, 2012

7

Herbal remedy-associated acute renal failure secondary to Cape aloes

Valerie A. Luyckx, Robert Ballantine, Magda Claeys, Filip Cuyckens, Hilde Van den Heuvel, Richard K. Cimanga, Arnold J. Vlietinck, Marc E. De Broe, Ivor J. Katz

Journal:

American Journal of Kidney Diseases

Année:

2002

Langue:

english

Fichier:

PDF, 54 KB

english, 2002

8

High-resolution MS: first choice for peptide quantification?

Dillen, Lieve, Cuyckens, Filip

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 729 KB

english, 2013

9

Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides

Dillen, Lieve, Cools, Willy, Vereyken, Liesbeth, Lorreyne, Willy, Huybrechts, Tinne, de Vries, Ronald, Ghobarah, Hesham, Cuyckens, Filip

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.81 MB

english, 2012

10

A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation

De Vijlder, Thomas, Valkenborg, Dirk, Lemière, Filip, Romijn, Edwin P., Laukens, Kris, Cuyckens, Filip

Journal:

Mass Spectrometry Reviews

Année:

2017

Langue:

english

Fichier:

PDF, 2.26 MB

english, 2017

11

Development of a method for the quantitative metabolite profiling of pharmaceutical drugs using HPLC-ICP-MS following pre-column derivatization of their amino and hydroxyl groups using 4-aminopyridine as a model compound

Li, Sanwang, Cuyckens, Filip, Lynen, Frederic, Vanhaecke, Frank

Journal:

Journal of Analytical Atomic Spectrometry

Année:

2019

Langue:

english

Fichier:

PDF, 1.98 MB

english, 2019

12

Strategies and analytical workflows to extend the dynamic range in quantitative LC–MS/MS analysis

Ediage, Emmanuel Njumbe, Aerts, Tania, Lubin, Arnaud, Cuyckens, Filip, Dillen, Lieve, Verhaeghe, Tom

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 694 KB

english, 2019

13

Characterization of organosulfates from the photooxidation of isoprene and unsaturated fatty acids in ambient aerosol using liquid chromatography/(−) electrospray ionization mass spectrometry

Yadian Gómez-González, Jason D. Surratt, Filip Cuyckens, Rafal Szmigielski, Reinhilde Vermeylen, Mohammed Jaoui, Michael Lewandowski, John H. Offenberg, Tadeusz E. Kleindienst, Edward O. Edney, Frank

Journal:

Journal of Mass Spectrometry

Année:

2008

Langue:

english

Fichier:

PDF, 352 KB

english, 2008

14

Direct stereochemical assignment of hexose and pentose residues in flavonoid O-glycosides by fast atom bombardment and electrospray ionization mass spectrometry

Filip Cuyckens, Abdelaaty A. Shahat, Luc Pieters, Magda Claeys

Journal:

Journal of Mass Spectrometry

Année:

2002

Langue:

english

Fichier:

PDF, 197 KB

english, 2002

15

Mass spectrometry in the structural analysis of flavonoids

Filip Cuyckens, Magda Claeys

Journal:

Journal of Mass Spectrometry

Année:

2004

Langue:

english

Fichier:

PDF, 76 KB

english, 2004

16

Determination of the glycosylation site in flavonoid mono-O-glycosides by collision-induced dissociation of electrospray-generated deprotonated and sodiated molecules

Filip Cuyckens, Magda Claeys

Journal:

Journal of Mass Spectrometry

Année:

2005

Langue:

english

Fichier:

PDF, 209 KB

english, 2005

17

Improved liquid chromatography—Online radioactivity detection for metabolite profiling

Filip Cuyckens, Valerie Koppen, Rainer Kembuegler, Laurent Leclercq

Journal:

Journal of Chromatography A

Année:

2008

Langue:

english

Fichier:

PDF, 781 KB

english, 2008

18

Mass spectrometric methods for the characterisation and differentiation of isomeric O-diglycosyl flavonoids

Yu-Liang Ma, Filip Cuyckens, Hilde Van den Heuvel, Magda Claeys

Journal:

Phytochemical Analysis

Année:

2001

Langue:

english

Fichier:

PDF, 121 KB

english, 2001

19

Structural characterization of flavonol di-O-glycosides from Farsetia aegyptia by electrospray ionization and collision-induced dissociation mass spectrometry

Abdelaaty A. Shahat, Filip Cuyckens, Wu Wang, Khaled A. Abdel-Shafeek, Husseiny A. Husseiny, Sandra Apers, Sabine Van Miert, Luc Pieters, Arnold J. Vlietinck, Magda Claeys

Journal:

Rapid Communications in Mass Spectrometry

Année:

2005

Langue:

english

Fichier:

PDF, 210 KB

english, 2005

20

IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers

Laurent Leclercq, Russell J. Mortishire-Smith, Maarten Huisman, Filip Cuyckens, Michael J. Hartshorn, Alastair Hill

Journal:

Rapid Communications in Mass Spectrometry

Année:

2009

Langue:

english

Fichier:

PDF, 700 KB

english, 2009

21

Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration

Filip Cuyckens, Rob Hurkmans, Jose M. Castro-Perez, Laurent Leclercq, Russell J. Mortishire-Smith

Journal:

Rapid Communications in Mass Spectrometry

Année:

2009

Langue:

english

Fichier:

PDF, 667 KB

english, 2009

22

Product ion mobility as a promising tool for assignment of positional isomers of drug metabolites

Filip Cuyckens, Carola Wassvik, Russell J. Mortishire-Smith, Gary Tresadern, Iain Campuzano, Jan Claereboudt

Journal:

Rapid Communications in Mass Spectrometry

Année:

2011

Langue:

english

Fichier:

PDF, 934 KB

english, 2011

23

Hyphenation of reverse-phase HPLC and ICP-MS for metabolite profiling—application to a novel antituberculosis compound as a case study

Lieve I. L. Balcaen, Björn De Samber, Kenny De Wolf, Filip Cuyckens, Frank Vanhaecke

Journal:

Analytical and Bioanalytical Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 453 KB

english, 2007

24

Fast high-performance liquid chromatography method for quality control of soy extracts

Sandra Apers, Tania Naessens, Katleen Van Den Steen, Filip Cuyckens, Magda Claeys, Luc Pieters, Arnold Vlietinck

Journal:

Journal of Chromatography A

Année:

2004

Langue:

english

Fichier:

PDF, 90 KB

english, 2004

25

Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata

Kenn Foubert, Filip Cuyckens, Ann Matheeussen, Arnold Vlietinck, Sandra Apers, Louis Maes, Luc Pieters

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 517 KB

english, 2011

26

HPLC/ICP-MS in Combination with “Reverse” Online Isotope Dilution in Drug Metabolism Studies

Meermann, Björn, Hulstaert, Anne, Laenen, Aline, Looveren, Cis Van, Vliegen, Maarten, Cuyckens, Filip, Vanhaecke, Frank

Journal:

Analytical Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 913 KB

english, 2012

27

In vitro studies on the metabolism of trabectedin (YONDELIS®) in monkey and man, including human CYP reaction phenotyping

Marc Vermeir, Alex Hemeryck, Filip Cuyckens, Andres Francesch, Marc Bockx, Jos Van Houdt, Kathleen Steemans, Geert Mannens, Pablo Avilés, Roland De Coster

Journal:

Biochemical Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 742 KB

english, 2009

28

Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

Leclercq, Laurent, Cuyckens, Filip, Mannens, Geert S. J., de Vries, Ronald, Timmerman, Philip, Evans, David C.

Journal:

Chemical Research in Toxicology

Année:

2009

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2009

29

Characterization of Polar Organosulfates in Secondary Organic Aerosol from the Green Leaf Volatile 3- Z -Hexenal

Shalamzari, Mohammad Safi, Kahnt, Ariane, Vermeylen, Reinhilde, Kleindienst, Tadeusz E., Lewandowski, Michael, Cuyckens, Filip, Maenhaut, Willy, Claeys, Magda

Journal:

Environmental Science & Technology

Année:

2014

Langue:

english

Fichier:

PDF, 3.06 MB

english, 2014

30

A pilot study on the use of laser ablation-ICP-mass spectrometry for assessing/mapping the distribution of a drug and its metabolites across the body compartments of rats

Izmer, Andrei, Gholap, Deepti, De Houwer, Kathleen, Cuyckens, Filip, Vanhaecke, Frank

Journal:

Journal of Analytical Atomic Spectrometry

Année:

2012

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2012

31

Quantitative LC-MS/MS analysis of azide and azidoalanine in in vitro samples following derivatisation with dansyl chloride

Dillen, Lieve, Sips, Luc, de Vries, Ronald, Borgmans, Carine, Vliegen, Maarten, Leclercq, Laurent, Cuyckens, Filip

Journal:

Analytical Methods

Année:

2013

Langue:

english

Fichier:

PDF, 521 KB

english, 2013

32

Characterization of metal complexes with metallothioneins in the liver of the carp Cyprinus carpio by reversed-phase HPLC with ICP-MS and electrospray ionization (ESI)-MS

Goenaga Infante, Heidi, Cuyckens, Filip, Van Campenhout, Karen, Blust, Ronny, Claeys, Magda, Van Vaeck, Luc, Adams, Freddy C.

Journal:

Journal of Analytical Atomic Spectrometry

Année:

2004

Langue:

english

Fichier:

PDF, 201 KB

english, 2004

33

A comparison between HPLC-dynamic reaction cell-ICP-MS and HPLC-sector field-ICP-MS for the detection of glutathione-trapped reactive drug metabolites using clozapine as a model compound

De Wolf, Kenny, Balcaen, Lieve, Van De Walle, Elke, Cuyckens, Filip, Vanhaecke, Frank

Journal:

Journal of Analytical Atomic Spectrometry

Année:

2010

Langue:

english

Fichier:

PDF, 266 KB

english, 2010

34

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: Optimization of chromatographic peak capacity

Dubbelman, Anne-Charlotte, Cuyckens, Filip, Dillen, Lieve, Gross, Gerhard, Hankemeier, Thomas, Vreeken, Rob J.

Journal:

Journal of Chromatography A

Année:

2014

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2014

35

Physiology-Based IVIVE Predictions of Tramadol fromin VitroMetabolism Data

T’jollyn, Huybrecht, Snoeys, Jan, Colin, Pieter, Van Bocxlaer, Jan, Annaert, Pieter, Cuyckens, Filip, Vermeulen, An, Van Peer, Achiel, Allegaert, Karel, Mannens, Geert, Boussery, Koen

Journal:

Pharmaceutical Research

Année:

2015

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2015

36

High volume injections of biological samples for sensitive metabolite profiling and quantitation

Koppen, Valerie, Jones, Russell, Bockx, Marc, Cuyckens, Filip

Journal:

Journal of Chromatography A

Année:

2014

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2014

37

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation

T’jollyn, Huybrecht, Snoeys, Jan, Vermeulen, An, Michelet, Robin, Cuyckens, Filip, Mannens, Geert, Van Peer, Achiel, Annaert, Pieter, Allegaert, Karel, Van Bocxlaer, Jan, Boussery, Koen

Journal:

The AAPS Journal

Année:

2015

Langue:

english

Fichier:

PDF, 1.66 MB

english, 2015

38

Use of relative 12 C/ 14 C isotope ratios to estimate metabolite concentrations in the absence of authentic standards

Cuyckens, Filip, Pauwels, Nadine, Koppen, Valerie, Leclercq, Laurent

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 964 KB

english, 2012

39

Identifying metabolite ions of peptide drugs in the presence of an in vivo matrix background

Cuyckens, Filip, Dillen, Lieve, Cools, Willy, Bockx, Marc, Vereyken, Liesbeth, de Vries, Ronald, Mortishire-Smith, Russell J

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.53 MB

english, 2012

40

Mass Spectrometry Imaging of Drug Related Crystal-Like Structures in Formalin-Fixed Frozen and Paraffin-Embedded Rabbit Kidney Tissue Sections

Bruinen, Anne L., van Oevelen, Cateau, Eijkel, Gert B., Van Heerden, Marjolein, Cuyckens, Filip, Heeren, Ron M. A.

Journal:

Journal of the American Society for Mass Spectrometry

Année:

2016

Langue:

english

Fichier:

PDF, 5.67 MB

english, 2016

41

Determination of the total drug-related chlorine and bromine contents in human blood plasma using high performance liquid chromatography-tandem ICP-mass spectrometry (HPLC-ICP-MS/MS)

Klencsár, Balázs, Bolea-Fernandez, Eduardo, Flórez, María R., Balcaen, Lieve, Cuyckens, Filip, Lynen, Frederic, Vanhaecke, Frank

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Année:

2016

Langue:

english

Fichier:

PDF, 539 KB

english, 2016

42

Enhanced performance for the analysis of prostaglandins and thromboxanes by liquid chromatography-tandem mass spectrometry using a new atmospheric pressure ionization source

Lubin, Arnaud, Geerinckx, Suzy, Bajic, Steve, Cabooter, Deirdre, Augustijns, Patrick, Cuyckens, Filip, Vreeken, Rob J.

Journal:

Journal of Chromatography A

Année:

2016

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2016

43

One drop chemical derivatization - DESI-MS analysis for metabolite structure identification

Lubin, Arnaud, Cabooter, Deirdre, Augustijns, Patrick, Cuyckens, Filip

Journal:

Journal of Mass Spectrometry

Année:

2015

Langue:

english

Fichier:

PDF, 859 KB

english, 2015

44

One drop chemical derivatization - DESI-MS analysis for metabolite structure identification

Lubin, Arnaud, Cabooter, Deirdre, Augustijns, Patrick, Cuyckens, Filip

Journal:

Journal of Mass Spectrometry

Année:

2015

Langue:

english

Fichier:

PDF, 170 KB

english, 2015

45

The application of liquid chromatography-electrospray ionization mass spectrometry and collision-induced dissociation in the structural characterization of acylated flavonol O-glycosides from the seeds of Carrichtera annua

Cuyckens, Filip, Shahat, Abdelaaty, Van den Heuvel, Hilde, Abdel-Shafeek, Khaled, El-Messiry, Moustafa, Seif-El Nasr, Medhat, Pieters, Luc, Vlietinck, Arnold, Claeys, Magda

Journal:

European Journal of Mass Spectrometry

Année:

2003

Langue:

english

Fichier:

PDF, 604 KB

english, 2003

46

High-Resolution Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging of Cisplatin-Induced Nephrotoxic Side Effects

Van Acker, Thibaut, Van Malderen, Stijn J.M., Van Heerden, Marjolein, McDuffie, James Eric, Cuyckens, Filip, Vanhaecke, Frank

Journal:

Analytica Chimica Acta

Année:

2016

Langue:

english

Fichier:

PDF, 3.84 MB

english, 2016

47

In vitro and PBPK based assessment of drug-drug interaction potential of canagliflozin

Mamidi, Rao N. V. S., Dallas, Shannon, Sensenhauser, Carlo, Lim, Heng Keang, Scheers, Ellen, Verboven, Peter, Cuyckens, Filip, Leclercq, Laurent, Evans, David C., Kelley, Michael F., Johnson, Mark D.,

Journal:

British Journal of Clinical Pharmacology

Année:

2016

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2016

48

Quantitative Metabolite Profiling of an Amino Group Containing Pharmaceutical in Human Plasma via Precolumn Derivatization and High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry

Li, Sanwang, Klencsár, Balázs, Balcaen, Lieve, Cuyckens, Filip, Lynen, Frederic, Vanhaecke, Frank

Journal:

Analytical Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 787 KB

english, 2017

49

Atmospheric Pressure Ionization Using a High Voltage Target Compared to Electrospray Ionization

Lubin, Arnaud, Bajic, Steve, Cabooter, Deirdre, Augustijns, Patrick, Cuyckens, Filip

Journal:

Journal of the American Society for Mass Spectrometry

Année:

2017

Langue:

english

Fichier:

PDF, 897 KB

english, 2017

50

Combined Liquid Chromatography-Infrared Ion Spectroscopy for Identification of Regioisomeric Drug Metabolites

Martens, Jonathan, Koppen, Valerie, Berden, Giel, Cuyckens, Filip, Oomens, Jos

Journal:

Analytical Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2017